CBD Better With Other Entourage Cannabinoids

Cannabidiol (CBD) ©-designer491 Fotolia

Cannabidiol (CBD) ©-designer491 Fotolia

CBD, the medically remarkable cannabinoid from marijuana works much better with other cannabinoids in ‘entourage.’ My last post covered some of the political wrangling, with some states passing CBD-only laws and thinking they are done with medical marijuana. This entourage effect proves them wrong, and show that whole plant extracts with multiple cannabinoids, especially THC, work far better than CBD-only medications.

A major problem with CBD-only medication is a bell-shaped dose-response. The authors of the new Israeli study point out that CBD, short for cannabidiol, provided powerful anti-inflammatory and pain relief when delivered orally or intraperitoneally, but the effect seemed highly dose-dependent. Too high or too low a dose of purified CBD provided less effect against inflammation and pain, making establishing dosing very difficult.

This problem was solved by using “plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD,” in other words, high CBD marijuana. The effects were spectacular:

In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.

Such powerful, predictable, and reproducible pain and inflammation relief enable clinicians to set dosages, a key need in using cannabis medicine.

Have you tried CBD or CBD with entourage cannabinoids for any condition? What were your results?

Related articles

Cannabis Entourage Medically Superior to CBD Alone

Medical CannabisCBD is a remarkably medically potent component of marijuana. One of over 60 cannabinoids, CBD, short for ‘cannabidiol,‘ has dozens of medical uses, including anti-seizure, anti-inflammation, anti-anxiety, antioxidant, anti-tumor and as treatment for pain. But new research confirms what has long been thought: CBD in addition to other entourage cannabinoids like THC is far superior medically to pure CBD.

Cannabidiol does not produce the ‘high’ associated with THC, another medically useful cannabinoid. This lack of psychotropic effect from CBD is highly esteemed by researchers (and politicians), if not necessarily by the patient.

Dr. Sanjay Gupta brought to awareness for many Americans his conversion to supporting medical cannabis and research and reporting on CBD treatment of intractable seizures in children.  The effectiveness of CBD to quiet seizures heretofore unstoppable by a flood of truly toxic drugs has led to the spectacle of, in America, of medical refugees having to leave their harsh home states and head to legal Colorado.

In the USA many state legislators, although often abhorrent to marijuana, have been unable to resist the logic of supplying this safe but effective anti-seizure medication to children in their states. Sometimes shamed by families testifying with their seizure-inflicted chidren many states have passed CBD-only (or low THC) availability laws. (Bizarrely, by doing so, states are violating federal law, as CBD remains a  Schedule I substance, deemed harmful and without medical value, and most worthy of harsh control. But that remains topic for another day.)

The danger here is that state legislators may then feel that they have done their part in supplying medical marijuana by giving CBD the OK, will resist widening choices even in light of evidence that “entourage” cannabis medications are superior.

The Israeli research, with important implications for dosing medical cannabis is linked below. It will soon be detailed in another post:

Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol

 

 

Cannabis Oil: A Medical Marvel For Your Skin?

Back massageAs medical and personal use of marijuana become increasingly legal, many new ways to intake cannabis are now available. In addition to inhaling smoke, people can benefit from the medical cannabinoids in cannabis by vaporizing, ingesting, and absorption via the skin.

Plant cannabinoids, such as THC and CBD,  are fat soluble and readily absorbed by the skin. These medicinal molecules may well be most perfectly administered, for many conditions, via topical products applied directly to the skin’s surface, such as cannabis-infused massage oil. To clarify, this is not “hemp oil” from the seeds of low cannabinoid hemp, but made from the flowers (buds) themselves, and filled with cannabinoids.

© freshidea - Fotolia.com

© freshidea – Fotolia.com

The importance of the endocannabinoid system (ECS) to the healthy functioning of the skin is only now becoming clear, as the profound ways the ECS effects all our systems are continually discovered. This system,with natural receptors (CB1 and CB2) found in brain, immune and most types of cells, including those in the skin, and natural endocannabinoids our bodies produce, are perhaps the greatest discoveries in human physiology of the last 50 years.

During these same time, researchers discovered the ability for plant based cannabinoids from cannabis, including THC and  CBD, to activate the ECS.  These cannabinoids offer great potential for preventing, treating, and curing common skin diseases. Massages using cannabis infused oil may be an optimal way to address skin maladies. Cannabinoids may be very useful in treating skin cancer.

The endocannabinoid anandamide (AEA) has been found to play a key role in the health of the skin, prompting these Italian researchers to study cannabinoids cannabidiol (CBD), cannabigerol (CBG), and  cannabidivarin (CBDV) to study effects on skin cells. The Italian study skipped THC because of its psychoactivity, but THC has been shown to be powerfully therapeutic. THC is actually closer to AEA in function than is CBD, so it would have been interesting if it were included in the study.

Many skin conditions are inflammatory in nature and the anti-inflammatory effects of cannabinoids on skin cells have been demonstrated. Both THC and CBD show anti-inflammatory effects.

Cannabinoids also act on the genetic level to help calm skin diseases. The field of Epigenetics studies how “molecular mechanisms in the environment control gene activity independently of DNA sequence.” Activities such as exercise and factors such as nutrition and stress can change how genes are expressed. Endocannabinoids made by your own cells and phytocannabiniods from cannabis sativa also can change genetic expression in medically useful ways, addressing diseases from psoriasis to cancer.

The report concluded: “These findings show that the phytocannabinoids cannabidiol and cannabigerol are transcriptional repressors that can control cell proliferation and differentiation. This indicates that they (especially cannabidiol) have the potential to be lead compounds for the development of novel therapeutics for skin diseases.”

THC infused oils may offer many benefits missing from potions without this main cannabinoid. One of these benefits might be the “psychoactivity” seemingly dreaded by cannabinoid researchers. Patients may well enjoy the blissful experience, and even consider it part of the cure.

Watch for Part 2 of this series for more on the science, on the new found epigenetic capabilities of cannabinoids, how marijuana’s amazing molecules adjust gene expression to protect skin.

Congressman Steve Cohen Calls for End of Schedule I for Cannabis

By Don Fitch

Steve Cohen

Congressman Steve Cohen

Steve Cohen, US Congressman from Tennessee, has called out Attorney General Eric Holder to end the ludicrous Schedule I legal status for cannabis. The Tennessee democrat (TN-09) is one of several US congresspersons working against continued marijuana prohibition.
Congressman Cohen is absolutely right when he speaks about the evils of Schedule I status, the most restrictive and punitive, for cannabis and hemp. These negatives include:

• Asset Forfeiture: Schedule I means marijuana “crimes” are among the most serious federal offenses, enabling draconian stealing of personal assets by the government.

• IRS 280E: This rule may cripple most cannabis businesses by disallowing common business deductions because of the illegality (especially Schedule I) of the product.

• Mandatory Minimums: Long prison terms for any “crime” involving cannabis are supported by the pernicious Schedule I tag.

• Medical Marijuana Research: Total control (and nearly total restriction) is granted to the DEA and NIDA, who cling to the “no medical use” definition to disallow medical research.

• Hemp: Imported seeds for the first Kentucky hemp planting were delayed at the border by the DEA last summer, requiring the intervention of Kentucky Senator Mitch McConnell. To survive, the new American hemp industry needs cannabis rescheduling. Continue reading