CBD Clues for ALS Treatment

Yet another study shows the potential usefulness of marijuana’s cannabinoids to treat ALS.

Cannabidiol Modulates Genes Linked with Amyotrophic Lateral Sclerosis is the partial title of a new article accepted for publication by the Journal of Cellular Biology.  ALS, amyotrophic lateral sclerosis, aka Lou Gehrig’s disease, is a miserable neuromuscular condition, terribly disabling and nearly always fatal. Like other degenerative, inflammatory diseases, ALS is associated with a demon’s brew of “oxidative stress, mitochondrial dysfunction, and excitotoxicity.”

Perhaps this century’s best know sufferer of ALS is physicist and cosmologist Steven Hawking. Defying the odds, Hawking has lived with this disease for nearly half a century. The ALS pathology has destroyed nerves controlling his muscles. As the nerves wasted, so did the muscles, confining Hawking to a wheelchair and robbing him of speech. But while these motor neurons have decayed, the cerebral neurons in his brain have soared into realms of thought few other humans have attained. He ponders, and rigorously researches, the biggest questions of space and time, black holes, and possible alien life. He cannot stand, yet he stands on the shoulders of Einstein, Copernicus, and Galileo.

A desire to conquer this cruel disease recently inspired many a Facebook video of a volunteer enduring drenching in the ALS Bucket Challenge. Perhaps they may find another glimmer of hope in this research.

Intriguingly, this in vitro study shows that CBD, or cannabidiol, modulates gene expression in stem cells (human gingiva-derived mesenchymal stromal cells (hGMSCs)) “connected with ALS pathology.”

The researchers gave reason for their research choice of CBD in their abstract:

Cannabidiol, a non-psychotrophic cannabinoid, has been demonstrated as a potent anti-inflammatory and neuroprotective agent in neurological preclinical models.

The research demonstrates yet another way CBD and other molecules from cannabis deliver innovative new tools for medical researchers and hope for those suffering neurodegenerative disorders.