Cannabinoid Receptors and Pain Relief with Acupuncture

Acupuncture has long been shown to relieve pain, but medical science lacked a mechanism to explain how it works. Now research out of Shanghai China reported in Evidence-Based Complementary and  Alternative Medicine finds that the cannabinoid system provides an answer.

The new research is entitled Electroacupuncture inhibition of hyperalgesia in rats with adjuvant arthritis: involvement of cannabinoid receptor 1 and dopamine receptor subtypes in striatum. The cannabinoid system is the regulatory system discovered and revealed over the past 25 years to play major roles in homeostasis and pain relief.  The cannabinoid receptor 1 mentioned is usually abbreviated CB1, and is the main receptor activated by cannabis (marijuana) and also by natural endocannabinoids produced by our bodies.

Based on their knowledge that dopamine D1/D2 receptors are involved in electroacupuncture analgesia, they conjectured that the  ” CB1 and dopamine systems sometimes interact and may operate synergistically in rat striatum.”  They found at the sites of two pain relieving acupuncture points “that the levels of CB1 expression in the repeated-EA group were much higher.”  They conclude, “these results suggested that the strong activation of the CB1 receptor after repeated EA resulted in the concomitant phenomenon of the upregulation of D1 and D2 levels of gene expression.” Activating these CB1 receptors turned on the D1/D2 receptor genes.

The authors conjectured, “One unproved but intriguing idea is that endocannabinoids may set the analgesic tone of the

© StockHouse - Fotolia.com

© StockHouse – Fotolia.com

body, with the level of their production acting as a kind of pain thermostat.” Again, the cannabinoid receptor system shows its huge importance in human physiology. Electroacupuncture and cannabis both activate the CB1 receptor and both result in pain relief.

Cinnamon, spices and cannabis for anti-inflammation.

Cinnamon

Cinnamon

Both the spice, cinnamon and the medicinal herb, cannabis, provide beneficial anti-inflammatory effects. At least some of these healthy effects are from stimulation of the same receptors in your endocannabinoid receptor system.

Although useful and beneficial when protecting the body against bacterial intruders and other perils, inflammation becomes a medical problem if it becomes chronic. Diseases ending in “itis,” such as arthritis and gingivitis are just two of dozens of such maladies, laden with toxic effects to the tissues affected and destructive to the body in general. Indeed, chronic inflammation has become a key medical villain in the degenerative diseases that bedevil modern society. Such inflammation is now seen as a generator of atherosclerosis and is a potent cardiovascular risk factor.

Cinnamon has long been recognized for health-enhancing properties, including providing anti-inflammatory effects. The spice’s component coumarin, in cinnamomum aromaticum thins the blood. Increasingly, cinnamon appears to be very useful in addressing insulin resistance and diabetes.

At least some of the spice’s anti-inflammatory properties come from its another component shared with other spices, beta-caryophyllene. Cloves, black pepper, rosemary, hops and other spices all provide this component of essential oils.

The plant cannabis also provides anti-inflammatory properties. Cannabinoids such as THC and CBD provide anti-inflammatory effects, but at least some of the anti-inflammatory properties of cannabis also come from the plant terpene, beta-caryophyllene.

Research published in 2008 by The National Academy of Sciences of the USA, an international team of researchers show that beta-caryophyllene is a dietary cannabinoid. A cannabinoid is a substance that activates (or otherwise modulates) our endocannabinoid receptor system. This newly discovered and ubiquitous system has been shown be be a key regulatory system for many of our body’s functions. Activation of the key components of this system, cannabinoid receptors, has been shown to provide health benefits. These receptors come in at least two types, CB1, found mainly on neurons but also elsewhere and CB2, found mainly on immune cells. Activation of CB1 receptors, primarily by THC, provides cannabis its psychotropic effect.

Activation of CB2 receptors, on the other hand, provokes no psychotropic response but does seem to provide useful modulation of the immune response. CB2 receptors are activated by THC, CBD (cannabidiol) and other cannabinoids, and the terpene beta-caryophyllene. CB2 receptor activation triggers an anti-inflammatory, neuron protecting response. The NSA research concludes it abstract with, “These results identify (E)-BCP (beta-caryophyllene) as a functional nonpsychoactive CB2 receptor ligand in foodstuff and as a macrocyclic antiinflammatory cannabinoid in Cannabis.

As a general anti-inflammatory tactic, consider adding or increasing cinnamon in your diet. Few foods are more nutritious and heart healthy than say, oatmeal flavored with natural cinnamon. Those battling insulin resistance and diabetes might find special benefit. A great move is to replace reduced salt in food with additional beta-caryophyllene bearing spices of several types.

Just be sure to eat your spices, not smoke them.