CBD Better With Other Entourage Cannabinoids

Cannabidiol (CBD) ©-designer491 Fotolia

Cannabidiol (CBD) ©-designer491 Fotolia

CBD, the medically remarkable cannabinoid from marijuana works much better with other cannabinoids in ‘entourage.’ My last post covered some of the political wrangling, with some states passing CBD-only laws and thinking they are done with medical marijuana. This entourage effect proves them wrong, and show that whole plant extracts with multiple cannabinoids, especially THC, work far better than CBD-only medications.

A major problem with CBD-only medication is a bell-shaped dose-response. The authors of the new Israeli study point out that CBD, short for cannabidiol, provided powerful anti-inflammatory and pain relief when delivered orally or intraperitoneally, but the effect seemed highly dose-dependent. Too high or too low a dose of purified CBD provided less effect against inflammation and pain, making establishing dosing very difficult.

This problem was solved by using “plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD,” in other words, high CBD marijuana. The effects were spectacular:

In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.

Such powerful, predictable, and reproducible pain and inflammation relief enable clinicians to set dosages, a key need in using cannabis medicine.

Have you tried CBD or CBD with entourage cannabinoids for any condition? What were your results?

Related articles

Cannabis Entourage Medically Superior to CBD Alone

Medical CannabisCBD is a remarkably medically potent component of marijuana. One of over 60 cannabinoids, CBD, short for ‘cannabidiol,‘ has dozens of medical uses, including anti-seizure, anti-inflammation, anti-anxiety, antioxidant, anti-tumor and as treatment for pain. But new research confirms what has long been thought: CBD in addition to other entourage cannabinoids like THC is far superior medically to pure CBD.

Cannabidiol does not produce the ‘high’ associated with THC, another medically useful cannabinoid. This lack of psychotropic effect from CBD is highly esteemed by researchers (and politicians), if not necessarily by the patient.

Dr. Sanjay Gupta brought to awareness for many Americans his conversion to supporting medical cannabis and research and reporting on CBD treatment of intractable seizures in children.  The effectiveness of CBD to quiet seizures heretofore unstoppable by a flood of truly toxic drugs has led to the spectacle of, in America, of medical refugees having to leave their harsh home states and head to legal Colorado.

In the USA many state legislators, although often abhorrent to marijuana, have been unable to resist the logic of supplying this safe but effective anti-seizure medication to children in their states. Sometimes shamed by families testifying with their seizure-inflicted chidren many states have passed CBD-only (or low THC) availability laws. (Bizarrely, by doing so, states are violating federal law, as CBD remains a  Schedule I substance, deemed harmful and without medical value, and most worthy of harsh control. But that remains topic for another day.)

The danger here is that state legislators may then feel that they have done their part in supplying medical marijuana by giving CBD the OK, will resist widening choices even in light of evidence that “entourage” cannabis medications are superior.

The Israeli research, with important implications for dosing medical cannabis is linked below. It will soon be detailed in another post:

Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol