CBD Clues for ALS Treatment

Yet another study shows the potential usefulness of marijuana’s cannabinoids to treat ALS.

Cannabidiol Modulates Genes Linked with Amyotrophic Lateral Sclerosis is the partial title of a new article accepted for publication by the Journal of Cellular Biology.  ALS, amyotrophic lateral sclerosis, aka Lou Gehrig’s disease, is a miserable neuromuscular condition, terribly disabling and nearly always fatal. Like other degenerative, inflammatory diseases, ALS is associated with a demon’s brew of “oxidative stress, mitochondrial dysfunction, and excitotoxicity.”

Perhaps this century’s best know sufferer of ALS is physicist and cosmologist Steven Hawking. Defying the odds, Hawking has lived with this disease for nearly half a century. The ALS pathology has destroyed nerves controlling his muscles. As the nerves wasted, so did the muscles, confining Hawking to a wheelchair and robbing him of speech. But while these motor neurons have decayed, the cerebral neurons in his brain have soared into realms of thought few other humans have attained. He ponders, and rigorously researches, the biggest questions of space and time, black holes, and possible alien life. He cannot stand, yet he stands on the shoulders of Einstein, Copernicus, and Galileo.

A desire to conquer this cruel disease recently inspired many a Facebook video of a volunteer enduring drenching in the ALS Bucket Challenge. Perhaps they may find another glimmer of hope in this research.

Intriguingly, this in vitro study shows that CBD, or cannabidiol, modulates gene expression in stem cells (human gingiva-derived mesenchymal stromal cells (hGMSCs)) “connected with ALS pathology.”

The researchers gave reason for their research choice of CBD in their abstract:

Cannabidiol, a non-psychotrophic cannabinoid, has been demonstrated as a potent anti-inflammatory and neuroprotective agent in neurological preclinical models.

The research demonstrates yet another way CBD and other molecules from cannabis deliver innovative new tools for medical researchers and hope for those suffering neurodegenerative disorders.

 

More Evidence Cannabinoid THCV Helps with Type 2 Diabetes

The alarming increase in diabetes, especially behavior-linked Type 2 diabetes, threatens this nation’s and the planet’s health care systems. With this disease, the body is unable to process enough sugar from the blood. This excess blood glucose damages nearly every organ and normal health process, causing much misery, and in some cases disabilities, amputations, blindness, and impotence. The disease doubles risk of early death.

New evidence helps establish the usefulness in the plant cannabinoid, THCV (tetrahydrocannabivarin), in helping control Type 2 diabetes. As reported previously in this blog, THCV appears to help less obesity.  A new study, reported by the International Association for Cannabinoid Medicines, appears soon in Diabetes Care. 2016 Aug 29. pii: dc160650. Titled, Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study, shows he beneficial effects on a number of diabetic indices.

Significantly, the authors found that “Compared with placebo, THCV significantly decreased fasting plasma glucose.” This removal of sugar from the blood is a basic goal of diabetes prevention and treatment. Additionally, they found improvements in:

  • Pancreatic β-cell function
  • Adiponectin levels
  • Apolipoprotein A

The authors assert in conclusion:

THCV could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.

Seminal cannabis researcher and discoverer of THC, Raphael Mechoulam, in British Journal of Pharmacology in 2005, discussed the apparent unique properties of THCV and posed several research questions. He notes, as has Scottish researcher Roger G. Pertwee, that THCV content can be very high in hashish from Pakistan. Despite these high levels of the supposed CB1 receptor antagonist THCV, Pakistani hashish has no apparent “downer” aspect depressing the user. Perhaps this is due to the presence of the other 60 cannabinoids.

Use of THCV as medical marijuana for obesity and diabetes prevention and treatment is made difficult by the lack of access to THCV-heavy or predominant strains. Durban Poison is probably the most available. Reviewer Ry Richard gave it kudos for energy.

“Durban is legendary for its almost electric effects package, which fills the user with a buzzing energy and a flurry of mental activity. It is the perfect variety for a productive day, as it is strong but tends to stay out of the way of most mental processes, allowing for a high level of functionality.”

Such high levels of energy could come in handy in assisting with other behavioral and lifestyle factors affecting glucose levels and other metabolic processes. Human bodies overly composed of fat cells and lacking in muscles cells become insulin resistant and cannot remove sufficient blood sugar. Lack of movement, such as prolonged sitting is a major metabolic risk factor on its own, causing “sitting diseases” of which obesity is one and diabetes another.

Physical movement, such as walking at least 10,000 steps a day, provides powerful preventive and treatment effects for pre-diabetics and those with the actual diagnosis. Adequate walking helps control excess fat while building muscle, and provides dozens of preventive health benefits. Jogging a few minutes per day in addition helps even more.

Muscle mass and muscle cells readily accept and burn glucose, removing it from the blood stream and turning it into energy instead of poison. In addition to movement, engaging in weight training or other muscle building regimen for just a few minutes every other day can quickly help build muscle mass to pull glucose from the blood and burn it up. By burning this energy, muscle mass also helps control obesity and, besides, looks darn good!

Help prevent and even treat diabetes and obesity with low sugar intake and high THCV cannabis, along with movement and muscle.

CBD Better With Other Entourage Cannabinoids

Cannabidiol (CBD) ©-designer491 Fotolia

Cannabidiol (CBD) ©-designer491 Fotolia

CBD, the medically remarkable cannabinoid from marijuana works much better with other cannabinoids in ‘entourage.’ My last post covered some of the political wrangling, with some states passing CBD-only laws and thinking they are done with medical marijuana. This entourage effect proves them wrong, and show that whole plant extracts with multiple cannabinoids, especially THC, work far better than CBD-only medications.

A major problem with CBD-only medication is a bell-shaped dose-response. The authors of the new Israeli study point out that CBD, short for cannabidiol, provided powerful anti-inflammatory and pain relief when delivered orally or intraperitoneally, but the effect seemed highly dose-dependent. Too high or too low a dose of purified CBD provided less effect against inflammation and pain, making establishing dosing very difficult.

This problem was solved by using “plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD,” in other words, high CBD marijuana. The effects were spectacular:

In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.

Such powerful, predictable, and reproducible pain and inflammation relief enable clinicians to set dosages, a key need in using cannabis medicine.

Have you tried CBD or CBD with entourage cannabinoids for any condition? What were your results?

Related articles

Hemp And Cannabis in Southern Oregon Skirmish

As Oregon’s legal marijuana market goes official on July 1, 2015, two different aspects of cannabis agriculture are at odds.

Some of the world’s finest wines are produced from grapes grown in southern Oregon. In nearby fields, some of the planet’s choicest cannabis strains benefit from the same climate. The medical marijuana plants appear like small trees, protruding with arm-sized buds worth big money when harvested, dried and trimmed.

Cannabis Bud

Cannabis Flower Without Seeds

The aromatic female cannabis flowers glisten as they await the wind-borne arrival of pollen from male cannabis so they can produce seeds and complete their reproductive cycle. But the pollen never arrives, as growers are quick to uproot any male plants. Pollination would ruin the monetary and medical value of the crop as surely as a late season hail storm. Sinsemilla (Spanish for “without seed”) cannabis can sell for up to two thousand dollars a pound; seeded marijuana has no market value.

Industrial hemp

Industrial hemp crop.

Now a new player is entering the Oregon cannabis agriculture: hemp. Like medically valuable sinsemilla, hemp is also marijuana, cannabis sativa. Unlike sinsemilla, hemp is grown for the seeds; they are the most valuable part of the hemp crop, although the entire plant is useful in dozens of ways. Indeed, hemp seeds themselves and the oil produced from them are arguably the world’s most nutritious food. They are sources of essential oils and proteins that our bodies cannot produce themselves, and they provide perfectly balanced omega 3 fatty acids, excellent nutrition for brain and body. If you were abandoned on a desert island with the choice of one food, hemp seeds might be your single best pick. Continue reading

Football Concussions and the Brain-Saving Effects of Cannabis

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© intheskies – Fotolia.com

The prevalence of brain injuries associated with football are becoming increasingly clear. More than anyone suspected, banging heads together in football causes mild (and not so mild) traumatic brain injuries( mTBI). New findings and the plights of many former players may fundamentally change the game of American football, from the NFL all the way down through college and high school to Pop Warner. The latter kid’s league is suffers declining participation as parents fear damage to their children’s brains.

During the same time period that the the severity of brain-damaging injuries suffered by football players was becoming clear, research in Israel and Spain began to show that the human brain is protected from TBI by the cannabinoids in cannabis.

It may well turn out to be that the best on-field treatment of a suspected concussion will be taking “hits” of vaporized cannabinoids, right from medical cannabis. Even now, portable vaporizers can be ready to provide a controlled dosage of cannabinoids within a few seconds.

At the same time, new helmets with  accelerometers for measuring impact force and gyrometers for measuring twist will help in the immediate assessment of possible concussion after a violent tackle or block. Perhaps LED lights will read out G force readings right on the helmet’s surface, allowing fellow players, coach, and trainer to spot potential dangers.

Imagine this scenario in the not-too-far future: At a home game in Seattle or Denver or other state with medical marijuana exemption to tyrannical federal marijuana laws, the home team quarterback sets his squad on a crucial third down. Unfortunately for him, he was swallowed in a pass rush; worse yet when he was floored by a 300 pound left tackle, his helmet smashed into that of another tackler at a high rate of force. He lay stunned, not quite sure why to get up. Coach and team physician approach at a jog alarmed to see the red glow from the helmet LED declaring a probably concussion. As the physician reads the G force readings from the collision, she clicks on the portable vaporizer. She asks the player a few questions, at which he performs badly. He can state his name but is unsure of the date, even the year. This, along with the red light concussion warning and the dangerously high deceleration ‘G’ rating, convinces her to act immediately, bringing the vaporizer to the injured player’s lips and telling him, “breathe in this medicine.”

As the brain-traumatized player inhales cannabinoids into his lungs, they quickly make it to his heart and fountain up to his brain. Within seconds the cannabinoids THC, CBD and others cross the blood-brain-barrier in his brain and begin their neuroprotective functions. In the injured brain, neurotransmitters, particularly glutamate, are overproduced in a frenzy that damages neurons. Inflammatory processes produce reactive oxygen species (ROS), dangling electrons that wound cell walls and DNA. In this unlikely scenario, total time from traumatic brain injury, to diagnosis, to treatment molecules reaching the site of injury was perhaps one minute. This may also be a future protocol in case of stroke, another source of traumatic brain injury.

In the brain these cannabinoids dampen down the frenzied, brain-damaging transmitters. Cannabinoids, including THC and CBD, reduce production of the transmitter glutamate. Cannabinoids also serve as antioxidants to sop up the dangerous ROS oxidants. They calm the brain and reduce inflammation.

In moves it looks like the NFL might actually do, the league should end any restriction for players using cannabis. Not only is it good for their battered brains but also offers the safest medication for several types of pain, including neuropathic pain. There is actually more justification for making cannabis use by NFL players mandatory than there good reasons for its prohibition. Strict enforcement of rules penalizing wounding play actions such as ‘helmeting’ will also help.

Medical Cannabis Refugees

Americans in dire need of medical cannabis for themselves or their children are being forced to flee to states with humane laws providing access to their medicine. For many people and especially parents, access to medical marijuana is literally a matter of life and death.  marijuana and pillsMost US states still adhere to draconian laws regarding any possession of cannabis and afford medical users no protection. Parents face prosecution, even loss of possession of their children for trying to supply them natural compounds that can save their children’s lives from slow death by seizures, sometimes hundreds a day.

Ironically, the main compound sought by these parents is the CBD or cannabidiol. Unlike psychoactive cannabinoid THC, CBD provides no ‘high,’ the mental state seemingly so feared by nearly all researchers. Nevertheless, CBD is itself classified, as are all cannabinoids from marijuana, as a Schedule I drug, highly dangerous and without medical value. This for a compound with no psychoactivity, nor toxicity that may well turn out to be one of the most significant medicines ever discovered. This is your government on drugs.

Certainly to a growing group of parents and stricken children in states like Colorado, CBD is a momentous medical godsend. As reported by CNN’s Sanjay Gupta in his documentary Weed, CBD strains of medical marijuana provide blessed relief from childhood seizures and developmental problems caused by Severe Myoclonic Epilepsy of Infancy (SMEI), aka Dravet Syndrome. Where mixtures of powerful and dangerous pharmaceutical drugs of every type had failed to stop the seizures, and almost killed their small patients, CBD tinctures provided immediate relief.

Seeing such dramatic improvement for such a heart-breaking condition, parents of children with similar conditions across the country of course became excited about the possibility of providing their infants with relief. But because medical cannabis research has been blocked by the DEA and Schedule I status, these new high-CBD medicines are in short supply, available (and legal) pretty much only in Colorado.

The situation is leading to a medical cannabis refugee movement from states with harsh and cruel laws to states where voter’s have mandated legal exemption for medical use, like Colorado, Washington, Oregon and California. The first two states on this list also now allow personal use of cannabis, again voted in by the citizens of Colorado and Washington.

An excellent series in the Salt Lake Tribune documents this process of “Families migrating to Colorado for a medical marijuana miracle.” The article’s author, Kirsten Stewart interviews physician Dr. Margaret Gebbe, who calls the results of CBD in treating these epilepsy disorders as “absolutely remarkable.” Dr. Gebbe is also interviewed by Dr. Sanjay Gupta in his Weed documentary.

Sanjay Gupta reports on a similar movement on an international scale, with his story on a British citizen traveling to the Netherlands for access to his preferred pain treatment, cannabis sativa. He shows Gupta vial after vial of pharmaceutical narcotics he has been prescribed but were ineffective and with mind numbing side effects. Treatment with cannabis is unavailable in England, making this middle age man, bedeviled by pain cross the channel as another medical cannabis refugee.

American states and world countries that recognize the idiocy of cannabis prohibition and the powerful medical potential of cannabis will prosper while providing hugely needed relief and succor to these refugees.

Copyright © 2013 by Don Fitch

Bad Day for Medical Liberty: US Supreme Court Denies Cannabis Rescheduling

© freshidea - Fotolia.com

© freshidea – Fotolia.com

Depressingly, the first thing the US Supreme Court did on its first Monday was to deny reconsideration of cannabis scheduling.

By refusing to appeal a lower ruling, the court locks in Schedule I (highly dangerous, no medical value) by allowing the DEA to make that decision. Read the gory details at StopTheDrugWar.org. This come out on the same day that Supreme Court Justice Antonin Scalia admits that he fully believes in the devil. His mindset would better fit Spain during the Inquisition than the USA in the 21st century. Yet we are stuck with his rulings.

There seems little chance now that the draconian Schedule I felonizing of cannabis will change, probably for decades to come. After all, it was just over 25 years that DEA law judge Francis L. Young told the truth about marijuana, including the fact that in no way should it be Schedule I. Yet a quarter century later, it still is. During these 25 years 20 million Americans have been unjustly arrested under these cruel laws.

With Schedule I intact,  the DEA and US Attorneys can continue to  jail Americans for decades along with seizing their property for the benefit of the agencies. States may legalize cannabis for medical or personal use all they want but as long as possession of any marijuana by anybody remains a stiff federal offense, the medical potential of cannabis will be blunted. The DEA and NIDA will still have control over research using cannabis, meaning they can continue to block nearly all medical marijuana research in the USA. This is probably the most cruel result.

It will also stifle and delay hemp production and use the USA.

For no good reason, tens of millions of Americans will have to continue to fear their government.

Who now is going to down-schedule or de-schedule  cannabis out of the hands of the DEA?

  • Certainly not the DEA itself. The felonization of cannabis is worth billions to the agency every year, no way they would consider changing it.

  • Barack Obama is highly unlikely to consider this desperately needed change; his presidency has been marked by increasing attacks on medical marijuana dispensaries and he has rejected any change of scheduling.

  • Even after 2016, it is unlikely the new president would make any change. Hillary Clinton has echoed Obama’s hard line. Joe Biden is one of the worst of the drug war criminals, enthusiastically creating the Drug Czar office and supporting harsh and authoritarian programs and policies his entire career. Although some libertarian republicans support ending drug prohibition and defunding the DEA, most republicans are staunch authoritarians who fully cheer and fund the war on drugs.

  • These leaves its to congress to change the scheduling.  Big hope there, huh?  Even if congress was not dysfunctional,  many congresspersons are former prosecutors, drug-war beneficiaries like Senator Jeff  “I love the DEA” Sessions, of the Judiciary Committee. Powerful house dinosaurs like Texas republican Arlen Smith headed off any reduction of federal persecution of medical cannabis in states where legal.

Future Americans will look back at us an wonder how we could have kept such dishonest and cruel laws so long.

Copyright © Don Fitch, 2013

 

 

Cannabinoids Combat Alzheimer’s Disease

It may be that small clumps of beta-amyloid protein begin causing Alzheimer’s disease (AD) by destroying the synapses between brain cells well before they form the plaques that have been associated with this memory-eroding and personality-robbing disorder. New research out of Stanford University reported in Science Digest (Scientists Reveal How Beta-Amyloid May Cause Alzheimer’s) found that these small bits of beta-amyloid protein clump together and, as bunches, bind with receptors on neurons.  This displaces connections with other neurons, destroying the synapses between that, in very real ways, make us who we are. Too many synapses destroyed  and soon you can’t remember Uncle Bob. Or your spouse.

© freshidea - Fotolia.com

© freshidea – Fotolia.com

Although in a way this is bad news–damage is taking place even before the plaque formation long thought to be the problem–the good news is that the finding may point to ways to help prevent the cruel disease with earlier intervention. Even better news is that a whole new class of preventive and therapeutic agents, cannabinoids, have been found to be very useful in curbing the ravages of Alzheimer”s disease. Cannabinoids are compounds that modulate specific receptors on brain cells, immune cells and other cells in the body. Three types of cannabinoids  exist: They can be produced by our bodies, by the plant cannabis, and synthetically in the laboratory. Last year Spanish researchers documented in the Journal of Neuroinflammation how cannabinoids are neuroprotective and anti-inflammatory agents with therapeutic potential,

Their research, entitled Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice. The Spaniards found that oral dosing with cannabinoids “ameliorates cognitive performance, decreases neuroinflammation and Aβ levels, likely by increasing its transport to the periphery.”  The cannabinoid treatment boosted memory and cognition, reduced brain inflammation and helped carry away the beta-amyloid tangles. What’s not to like! Yet again have cannabinoids been found to have powerful and beneficial medical effects, providing neuroprotection against one of the more cruel diseases to strike modern humans.

The Spanish research investigated synthetic cannabinoids, but earlier research found powerful AD preventive effects from THC, the primary psychoactive component of cannabis9-tetrahydrocannabinol). Astoundingly, researchers found when “compared to currently approved drugs prescribed for the treatment of Alzheimer’s disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.”  The enzyme acetylcholinesterase (AChE) promotes beta-amyloid clumping; THC prevents this clumping by binding with receptors on AChE molecules. Some pharmaceutical drugs use the same tactic, but THC was far more effective! On another AD front, researchers in 2013 declared that deficiency in density of CB1 receptors, the receptors activated by THC to produce psychoactivity along with a host of preventive, curative and palliative effects, resulted in worsened AD symptoms.

Fear of losing their memory and personalities to cruel diseases like Alzheimer’s is the number one anxiety of those over 50 years of age. This group should be aware that cannabinoids, even THC, can provide protection for brain cells help stave off dementia-producing inflammation and beta-amyloid clumping.

Copyright © Don Fitch

So Sayeth Sanjay! On cannabis, “We have been terribly and systematically misled for nearly 70 years.”

Medical Marihuana

Medical Marihuana
© goshiva – Fotolia.com

This writer called it a heart-breaker at the time in early 2009 when neurosurgeon Dr. Sanjay Gupta said he “would vote no on pot.”  Dr. Gupta’s dismissal of medical marijuana was disappointing because, as I noted, he was “brilliant, telegenic, a neurosurgeon, had huge recognition and an is excellent communicator.” Now forward 4 1/2 years and Sanjay Gupta’s views have come around 180 degrees. Incredibly, he now says, “Well, I am here to apologize. I mistakenly believed the Drug Enforcement Agency listed marijuana as a schedule 1 substance because of sound scientific proof.”

Sanjay now knows, after long investigation, that “We have been terribly and systematically misled for nearly 70 years in the United States, and I apologize for my own role in that.”  He pretty much calls out the DEA as the liars that they are.  One may question why such a brilliant man could have ever believed DEA lies, but the important thing now is that he knows better, and is communicating the truth.

He should have called his documentary Cannabis, rather than Weed,  the term preferred by cops. But for now, truth wins out as Dr. Sanjay Gupta speaks out.  See it on CNN August 11, 2013.